Abstract Expressionism is no longer regarded as cutting edge, having been replaced by a variety of other ‘isms’, but many artists reflecting that style continue to be some of the most recognized in the art market today. Other participating artists remain little known for a variety of reasons, including abandonment of the style, little marketing promotion, racial discrimination and inability to get gallery exhibition space. The artist list accompanying this essay reflects the better and lesser-known early Abstract Expressionists including some who totally turned away from the style.
If you have information to contribute on this subject, contact us via email: [email protected]
Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for the treatment of asthma in both children and adults. However, its effectiveness is debated, and recent studies have reported several adverse events such as neuropsychiatric disorders and allergic granulomatous angiitis. This study aims to obtain more insight into the safety profile of montelukast and to provide prescribing physicians with an overview of relevant adverse drug reactions in both children and adults. We retrospectively studied all adverse drug reactions on montelukast in children and adults reported to the Netherlands Pharmacovigilance Center Lareb and the WHO Global database, VigiBase ® until 2016. Depression was reported most frequently in the whole population to the global database VigiBase ® (reporting odds ratio (ROR) ; 95% CI: –). In the VigiBase ® , aggression was reported the most in children (ROR, ; 95% CI: –). Headaches were reported the most frequently to the Dutch database (ROR, ; 95% CI: –). Furthermore, nightmares are often reported for both children and adults to the Dutch and the global database. Eight patients with allergic granulomatous angiitis were reported to the Dutch database and 563 patients in the VigiBase ® . These data demonstrate that montelukast is associated with neuropsychiatric adverse drug reactions such as depression and aggression. Especially in children nightmares are reported frequently. Allergic granulomatous angiitis is also reported, a causal relationship has not been established.